Everything about ceesdekker.net

Everything about ceesdekker.net

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‘Indeed, that may be about proper. I seek for a physical comprehension of Organic methods in the base-up way. I think you might distinguish a few lines of analysis in my group at the moment. The primary fears chromosome structure: How would you have a metre-long DNA polymer folded and organised in such a microscopic cell? We have now made visualisation methods that let us to review how, for example, SMC proteins loop DNA (video on Youtube) as a way to Make up chromosomes.

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Regretably, For a long time after Iijima’s report, the manufacture of clean nanotubes was cumbersome. In 1996, even so, the team of Richard Smalley at Rice University managed to create one-walled carbon nanotubes at significant produce. Soon right after, I contacted Smalley, and we made a decision to join forces to evaluate the transportation through a solitary carbon nanotube.

2015, discovery that condensin is actually a extremely adaptable protein framework; and initial detection of DNA knots using nanopores

Illustration (3) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in ceesdekker gray, the rim with the pore is highlighted in crimson, and a 3D rendering with the motion of your DNA rod is shown.

Considering the fact that 2000 he moved to solitary-molecule biophysics and nanobiology, with analysis from DNA supercoiling scientific studies of nucleosomes and DNA restore proteins to DNA translocation through nanopores. A short while ago his research has centered on learning cell division with micro organism on chip, even though his greatest desire is from the route of realizing artificial cells.

Atomic force microscopy displays that vaccinia topoisomerase IB generates filaments on DNA in a very cooperative fashion

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At this time, we also realized that it ought to be probable to employ one semiconducting carbon nanotube for making a transistor — and we established out to make it. We stretched person semiconducting nanotubes throughout metallic electrodes and made use of the fundamental silicon substrate being a gate electrode, setting up the basic a few-terminal format of a field-outcome transistor (Fig.

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2001, discovery of single-electron transistors at space temperature depending on nanotubes; realization of very first logic circuits with carbon nanotube units; and discovery on the molecular framework of DNA mend enzymes with AFM

Allow’s very first seem again at this time when you decided to shift your concentrate from superconductivity and nanotubes to biology at the end of the 1990s.

Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and single-molecule experiments